Medical and Health Care

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Weakness (Generalised Fatigue & Reduced Strength)

Differential Breakdown

Possible Causes

Anaemia (iron, B12, folate)

Hypothyroidism

Electrolyte disorders (Na/K/Mg/Ca)

Chronic disease (CKD, CHF, COPD)

Vitamin deficiencies (D/B1/B6)

Myopathy / neuropathy

Adrenal insufficiency (Addison’s)

Investigations

Baseline

FBC

U&E, calcium, magnesium

B12, folate

TFT

Vitamin D

HbA1c

If neurological involvement suspected

Creatine kinase (CK)

ESR/CRP

Myositis antibodies (Mi-2, Jo-1)

Emergency Signs

Sudden paralysis

Respiratory compromise

Confusion or arrhythmia (electrolyte danger)